In 2004, Tom Aufderheide and Keith Lurie made an investigation regarding the impact of hyperventilation during cardiopulmonary resuscitation.

This investigation consisted of two studies, a clinical trial and a porcine animal study, and was published in the Critical Care Medicine journal. (https://journals.lww.com/ccmjournal/Abstract/2004/09001/Death_by_hyperventilation__A_common_and.2.aspx)

Even though professional rescue personnel were trained to follow the AHA guidelines of 12 breaths per minute, the average ventilation rate measured in adults cardiac arrest patients was 30 breaths/min.

No patient survived.

Survival studies in pigs demonstrated that hyperventilation decreased coronary perfusion and survival rates by over 70%.